Smoking and Skin Disorders

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John (Gold)	Smoking and Skin Disorders		Lead	[-]
11/05/07 06:12	Tags : None Smoking and Skin Disorders A number of medical studies examine smoking's impact upon skin. This thread is for sharing articles and study abstracts relating to skin conditions associated with smoking, nicotine or tobacco use. Keeping our dependency arrested while turning these elevated risks around and getting them headed in the opposite direction requires adherence to just one rule ... no nicotine today, Never Take Another Puff, Dip or Chew!
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John (Gold)	Smoking and Skin Disorders	#1	[url]	[-]
11/05/07 06:38	Second primary tumors following tobacco dependence treatments among head and neck cancer patients Am J Clin Oncol. 2007 Oct;30(5):531-9. Garces YI, Schroeder DR, Nirelli LM, Croghan GA, Croghan IT, Foote RL, Hurt RD. Division of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. garces.yolanda@mayo.edu Abstract OBJECTIVES: To estimate the cumulative percentage of second primary tumors (SPTs) in head and neck (H&N) cancer patients and primary cancers in general Nicotine Dependence Center (NDC) population controls following tobacco dependence consultation seen between 1988 and 2001. METHODS: A 1:1 matched pair design and a stratified Cox proportional hazard model were used. General NDC population controls were matched on age, gender, and NDC consult (type and date) to the H&N cancer patients. The study population included 101 H&N cancer patients (66 male, 35 female) with mean (SD) age of 58.7 (10.1) years. RESULTS: Baseline demographics and length of follow-up were similar between groups. However, H&N cancer patients smoked more cigarettes per day than controls (P < 0.003). For H&N cancer patients, the median time from initial H&N cancer diagnosis to NDC consult was 7 months (range, 0-292 months). Following the NDC consult, 27 H&N cancer patients developed 32 SPTs; whereas among the controls, 12 patients developed 12 other cancers (P = 0.013). There was no difference in the development of non-tobacco-related cancers (P = 0.273). However, H&N cancer patients were more likely to develop tobacco-related cancers (P = 0.01). Furthermore, there was a trend where the H&N cancer patients who continued to use tobacco were more likely to develop tobacco-related cancers than those who remained abstinent (P = 0.10). CONCLUSIONS: These findings confirm that H&N cancer patients are more prone to the development of tobacco-related cancers. Further, these findings suggest that H&N cancer patients who stop using tobacco are able to decrease the development of tobacco-related SPTs. PubMed Link to Study Abstract
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John (Gold)	Smoking and Skin Disorders	#2	[url]	[-]
11/05/07 06:39	Smoking and the Risk of Psoriasis in Women: Nurses' Health Study II The American Journal of Medicine Volume 120, Issue 11, November 2007, Pages 953-959 Arathi R. Setty MD, MPHa, b, Gary Curhan MD, ScDb, c, d and Hyon K. Choi MD, DrPHb, e, , aDepartment of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Bo ston, Mass bChanning Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass cRenal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass dDepartment of Epidemiology, Harvard School of Public Health, Boston, Mass eRheumatology Division, Arthritis Research Centre of Canada, Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC Available online 30 October 2007. Abstract Background Psoriasis is a common, chronic, inflammatory skin disorder. Smoking may increase the risk of psoriasis, but no prospective data are available on this relation. Methods We prospectively examined over a 14-year time period (1991-2005) the relation between smoking status, duration, intensity, cessation, and exposure to secondhand smoke, and incident psoriasis in 78,532 women from the Nurses Health Study II. The primary outcome was incident, self-reported, physician-diagnosed psoriasis. Results We documented 887 incident cases of psoriasis. Compared with those who had never smoked, the multivariate relative risk (RR) of psoriasis was 1.78 (95% confidence interval [CI], 1.46 to 2.16) for current smokers and 1.37 (95% CI, 1.17 to 1.59) for past smokers. Compared with nonsmokers, the multivariate RR of psoriasis was 1.60 (95% CI, 1.31 to 1.97) for those who had smoked 11-20 pack-years and 2.05 (95% CI, 1.66 to 2.53) for those who had smoked ≥21 pack-years. Compared with never smokers, the multivariate RR of psoriasis was 1.61 (95% CI, 1.30 to 2.00) for those who quit smoking <10 years ago, 1.31 (95% CI, 1.05 to 1.64) for 10-19 years ago, and 1.15 (95% CI, 0.88 to 1.51) for ≥20 years ago. Prenatal and childhood exposure to passive smoke was associated with an increased risk of psoriasis. Conclusions In this prospective analysis, current and past smoking, and cumulative measures of smoking were associated with the incidence of psoriasis. The risk of incident psoriasis among former smokers decreases nearly to that of never smokers 20 years after cessation. Keywords: Cessation; Cigarette; Cohort; Pack-years; Passive; Prospective; Psoriasis; Risk factors; Smoking http://www.sciencedirect.com/science/journal/00029343
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